Endocrine Abstracts

Introduction: Ephrin receptors (EPHs) compose the largest known subfamily of receptors tyrosine kinases and are bound and interact with EPHs-interacting proteins (Ephrins). They have a role in tumor growth, invasion, angiogenesis and metastasis of several neoplasms. Aim of the study was to investigate the expression of EPH-A4, -A5, -B2 and -B5 in pituitary lesions. Material and Methods: Our study group consisted of 18 patients (9 males with median age 54...

Background: Extrapulmonary PD NECs carry a poor prognosis. Some studies suggest cisplatin is more appropriate for younger patients due to its increased potency and nephrotoxicity compared to carboplatin, but randomized trials are lacking. We aim to determine whether there is a difference in outcomes for cisplatin vs carboplatin while adjusting for possible confounding factors.Methods: We identified PD NEC patients at Mayo Clinic between 2000-2022. Kaplan...

Background: A growing body of evidence reports implications of a direct extra-gonadal effect of follicle stimulating hormone (FSH), involving the development of obesity. The aim of this study was to evaluate the associations between traditional and local obesity indices and FSH concentrations in women after menopause.Methods: We evaluated a total of 420 postmenopausal women in a cross-sectional design (age 55.6±6.5 years, BMI were 25.8±4.0 kg/m...

Introduction: Sporadic primary hyperparathyroidism (sporadic PHPT) is a common endocrine disorder, usually caused by a single parathyroid adenoma. However, up to 15% of patients present with multiple gland disease (MGD), which cannot be always diagnosed preoperatively, raising serious management problems. No predictive genetic screening tests are currently available to distinguishing adenomas from MGD in sporadic PHPT. MiRNAs are widely established as genetic molecules that ha...

Background: Sulfonylureas (SUs) are known to increase fasting insulin levels in patients with Type 2 Diabetes (T2D) treated with these agents. Whether this increase is related to a greater risk of hypoglycemia has not yet been sufficiently elucidated.Methods: The study included 58 patients with T2D who had been on treatment with SUs, but not insulin, for more than 2 years. Confirmed hypoglycemic episodes during the past year were self-reported by the pat...

Introduction: Although computed tomography (CT) is the best mean to identify adrenal neoplasms there is still controversy of the concordance of the estimated radiological and histological size of the lesion. Since the size of adrenal tumours is a major criterion for surgical excision, we investigated whether recent and more sophisticated imaging techniques, can more accurately predict tumor’s size.Methods: We have retrospectively analyzed a series o...

Introduction: Extended Forsteo® Observational Study (ExFOS), a multinational, non-interventional, prospective, observational study, designed to evaluate fractures, back pain (BP), adherence and health-related quality of life (QoL) in teriparatide (TPTD) treated patients, based on the extension of treatment duration (24 months) and the addition of new indications (glucocorticoid-induced and male osteoporosis) was compared with EFOS.Methods...

Introduction: Virilizing tumors are rare, but frequent cause of virilization in postmenopausal women.Case report: A 62-year-old postmenopausal woman presented with a rapid onset of hirsutism with increased terminal hair growth, particular on chin and abdomen, frontal male pattern balding in the last 5 months. Physical examination revealed a low-pitched, deepened voice and clitoromegaly. The Ferriman–Gallwey score was 18. Laboratory evaluation: Testo...

Introduction: The 2017 WHO Classification of Pituitary Tumors grades silent corticotroph adenomas (SCAs) as high-risk adenomas due to their aggressive clinical behaviour (high probability of recurrence). Nonetheless, studies comparing recurrence rates of SCA with other non-functioning pituitary adenomas (NFPAs) subtypes have provided conflicting results necessitating review of the evidence this recommendation relies on.Aims: To estimate recurrence rates ...

Brown adipose tissue (BAT) is present in small quantities in human adults (~100 g) and can have a significant influence on metabolism. This effect is mediated by rapid activation of the BAT specific uncoupling protein 1 (UCP1), following stimulation of β-adrenergic receptor (AR) by the sympathetic nervous system. AR agonists stimulate rodent BAT, but have so far provided inconsistent findings in humans when administered orally (Vosselman et al. 2012). Rapid activ...